… establish the pharmacokinetics (PK) of allopurinol and oxypurinol, and the pharmacodynamics
(… The dosage used and the effect of allopurinol in this population, either or not undergoing …

… In this analysis, F m was used to represent the fraction of the allopurinol dose systemically
available as oxypurinol and K fm denotes the formation rate constant, similar to a previous …

… the exposure of serum oxypurinol, the active metabolite of allopurinol.These two transporters…
were estimated, where fm represents the fraction of allopurinol dose available as oxypurinol …

… In our present work, we achieved recoveries of 74 % and 100 % respectively for
allopurinol and oxypurinol from clinical canine urine samples, which we consider superior. …

… Allopurinol is metabolized to oxipurinol, and hypouricaemic efficacy of allopurinol is due …
Objective: To study and compare the bioavailability and bioequivalence of two allopurinol 300 …

… to allopurinol and the conversion of allopurinol to oxypurinol, and to determine a minimum
therapeutic oxypurinol … , controlled, parallel-group, comparative clinical trial were analyzed. …

… and evaluate an allopurinol adherence tool based on steadystate oxypurinol plasma
concentrations, allopurinol’s active metabolite. Methods. Plasma oxypurinol concentration were …

… among patients with gout; 18 this study also showed that allopurinol does not influence the
pharmacokinetics of verinurad. Oxypurinol exposure was lower on day 7/9 compared with …

… allopurinol treatment response, however, the association with plasma allopurinol or oxypurinol
… extensively studied for an association with altered oxypurinol pharmacokinetics (PKs). …

… oxypurinol was less effective than allopurinol both in vivo and in vitro. We show that upon
reoxidation to Mo(VI), oxypurinol … , hypoxanthine, or allopurinol is required for reformation of the …